UNH - Unité de Nutrition Humaine
Our unit
Diary
R
Adrien Rossary
Adrien Rossary2.jpg
Rossary Adrien
adrien.rossary@uca.fr
04 73 17 80 50
UCA
ECREIN
University Professor - Second Director

Research activity

Our research theme aims to understand the impact of nutrition on the functions of immunocompetent cells (ICCs) and their adaptive capacities during aging and chronic diseases. Currently, we have focused on different aspects during breast carcinogenesis in obesity :

  • Study of the modulation of cellular oxidative status in vitro and in vivo in the context of aging and pathology,
  • Exploration of cellular metabolism in oxidative stress and inflammation phenomena,
  • Metabolic characterization of CICs, particularly in terms of oxidative stress,
  • Characterization of the dialogue between CICs and their microenvironment,
  • Study of redox-sensitive cellular signaling pathways,
  • Characterization of inflammation, cytokines, and tissue metabolites,
  • Understanding the mechanisms by which physical activity modulates the anti-tumor response of CICs,
  • Search for nutritional bioactives of interest for the modulation of redox-sensitive pathways.

Most notable publications

  • Spontaneous Physical Activity in Obese Condition Favours Antitumour Immunity Leading to Decreased Tumour Growth in a Syngeneic Mouse Model of Carcinogenesis. Le Guennec, D.; Goepp, M.; Farges, M.-C.; Rougé, S.; Vasson, M.-P.; Caldefie-Chezet, F.; Rossary, A. Cancers 2022, 14, 59. https://doi.org/10.3390/cancers14010059
  • Modulation of inter-organ signalling in obese mice by spontaneous physical activity during mammary cancer development. Le Guennec D, Hatte V, Farges MC, Rougé S, Goepp M, Caldefie-Chezet F, Vasson MP, Rossary A. Sci Rep. 2020 May 29;10(1):8794. doi: 10.1038/s41598-020-65131-9.
  • EO771, the first luminal B mammary cancer cell line from C57BL/6 mice. Le Naour A, Koffi Y, Diab M, Le Guennec D, Rougé S, Aldekwer S, Goncalves-Mendes N, Talvas J, Farges MC, Caldefie-Chezet F, Vasson MP, Rossary A. Cancer Cell Int. 2020 Jul 20;20:328. doi: 10.1186/s12935-020-01418-1. eCollection 2020.
  • The interrelationship between physical activity and metabolic regulation of breast cancer progression in obesity via cytokine control. Le Guennec D, Rossary A. Cytokine Growth Factor Rev. 2020 Apr;52:76-87. doi: 10.1016/j.cytogfr.2020.02.001. Epub 2020 Feb 4.
  • Activation of antioxidant defences of human mammary epithelial cells under leptin depend on neoplastic state. Mahbouli S, Talvas J, der Vartanian A, Ortega S, Rougé S, Vasson MP, Rossary A. BMC Cancer. 2018 Dec 18;18(1):1264. doi: 10.1186/s12885-018-5141-8.

Recherche - Archive ouverte HAL

Other link

ECREIN