PROTéine HomEOSTAsie-SIgnalisation-Stress

Many pathologies, as well as aging, are associated with an alteration of protein and amino acid (AA) homeostasis, which can lead to a catabolic state. The resulting loss of muscle mass deteriorates the health of individuals and reduces the effectiveness of treatments. The development of effective interventions to reduce or prevent these deregulations is therefore a major medical challenge. The work of the PROTEOSTASIS team aims to characterize the mechanisms regulating protein/AA homeostasis with the general objective of developing nutritional and/or pharmacological strategies to maintain this homeostasis and counter muscle atrophy, particularly in the context of various pathologies (cancers, renal failure), physical inactivity or specific nutritional situations (malnutrition, undernutrition, etc.).

In this context, the PROTEOSTASIS team develops research at different complementary levels : understanding the mechanisms ; finding solutions for preventing, diagnosing and treating alterations ; and transferring these solutions to the clinic. To this end, the team's work is based on a wide variety of approaches and models, including cell lines, transgenic mice, a bio-inspired approach and studies in humans.