Maintaining muscle and bone mass

Longer life expectancy in developed countries is associated with the emergence of degenerative pathologies, which contribute to increasing the burden on public health systems. Aging is characterized by the development of sarcopenia, defined as the involuntary loss of muscle mass and function, and osteoporosis, leading to excessive skeletal fragility. These conditions are partly responsible for the loss of mobility, frailty and morbidity of the elderly. In addition, muscular atrophy and osteoporosis are often associated with pathological conditions whose incidence increases with age, resulting in high hospitalization costs. Preventing muscle wasting and osteoporosis would therefore contribute to maintaining autonomy and good health, as well as reducing public health costs.

The main objective here is to study musculoskeletal health with the aim of enabling healthy living through appropriate dietary patterns or nutrient intakes, and is organized around several lines of research :

1.    Understanding the mechanisms and metabolic alterations responsible for muscle wasting and osteoporosis, or their aggravation during pathophysiological states (aging, obesity, cancer, diabetes, catabolic states, etc.), in vivo (human, animal) and in vitro. 
2.    Develop new nutritional strategies to prevent musculoskeletal disorders in the context of physiological (aging) or pathological (chronic, metabolic diseases, etc.) conditions, and apply these new strategies to healthy or sick people to preserve their mobility and quality of life.