Research Activity

During obesity and sarcopenia, significant changes in body composition occur, with a lean mass/fat mass ratio favoring the latter. These changes are associated with metabolic disturbances such as insulin resistance. Are tissue secretions involved in these changes? What are the mediators ? Can nutrition modify the secretory profile of tissues ? How can sarcopenic obesity be diagnosed and prevented ? To answer these questions, I implement in vitro and preclinical models in addition to clinical data. All this while drawing on the laboratory's expertise in protein and lipid metabolism. I will then be able to assess the communication between adipose tissue and muscle and propose a clinical application of these findings. An initial in vitro study conducted in the laboratory allowed us to observe that secretions from insulin-resistant adipocytes are capable of transmitting altered insulin signaling to healthy differentiated muscle cells. In clinical practice, I study the role of diagnostic criteria in screening for sarcopenic obesity and I search for new markers and scores that can promote early detection.

Most notable publications

• Benz E, Pinel A, Guillet C. et al. (2024). Sarcopenia and Sarcopenic Obesity and Mortality Among Older People. JAMA Netw Open.
• Pinel A, Guillet C, Capel F. et al. (2024) Identification of factors associated with sarcopenic obesity development: Literature review and expert panel voting. Clin Nutr.
• Pouget M, Pinel A, Miolanne M. (2024), Improving the functional detection of sarcopenic obesity: prevalence and handgrip scoring in the OBESAR cohort. Obesity (Silver Spring).
• Pinel, A., Rigaudière, J-P., Jouve, C., Capel F. (2018). Modulation of Insulin Resistance and the Adipocyte-Skeletal Muscle Cell Cross-Talk by LCn-3PUFA. Int J Mol Sci.
• Pinel, A., Pitois, E. et al. (2016). "EPA prevents fat mass expansion and metabolic disturbances in mice fed with a Western diet." J Lipid Res.

Other links

• https://www.linkedin.com/in/alexandre-pinel-923723ba/
• ASMS