Research activity

My activity consists of developing research projects in the field of metabolomic and epidemiology. In particular, the objective is to study the phenotypes that are characteristic of the first metabolic deviations associated with the development of chronic metabolic diseases, as well as their main determinants and modulators. One of the main challenges is indeed to obtain, from phenotyping data, a more precise modelling of these pathologies in order to better define the phenotypes and their interrelationships. It requires the development of data processing strategies aimed at increasing the ability to extract and interpret the numerous data produced.

Publications

A cooperative learning framework for the integration of metabolomic data from multiple cohorts and common phenotype identification. E. Salanon, E. Jules, B. Comte, J. Boccard, Estelle Pujos-Guillot (2026). Computational and Structural Biotechnology Journal, 31, 346-354, [Research article]

Scaling-up metabolomics: Current state and perspectives. Hajjar G, Barros Santos M C, Bertrand- Michel J, Canlet C, Castelli F, Creusot N, Dechaumet S, Diémé B, Giacomoni F, Giraudeau P, Guitton Y, Thévenot E, Tremblay-Franco M, Junot C, Jourdan F, Fenaille F, Comte B, Pétriacq P, Pujos-Guillot E., TrAC Trends in Analytical Chemistry, 167 (20), 117225 (2023). [Research article]

Multiplatform metabolomics for an integrative exploration of metabolic syndrome in older men. Comte B, Monnerie S, Brandolini-Bunlon M, Canlet C, Castelli F, Chu-Van A, Colsch B, Fenaille F, Joly C, Jourdan F, Lenuzza N, Lyan B, Martin JF, Migné C, Morais JA, Petera M, Poupin N, Vinson F, Thevenot E, Junot C, Gaudreau P, Pujos-Guillot E. EBioMedicine. 2021 Jul;69:103440 [Research article]

Multi-block PLS discriminant analysis for the joint analysis of metabolomic and epidemiological data. Brandolini-Bunlon M, Pétéra M, Gaudreau P, Comte B, Bougeard S, Pujos-Guillot E. Metabolomics 3;15(10):134 (2019). [Research article]

Identification of Pre-frailty Sub-Phenotypes in Elderly Using Metabolomics. Pujos-Guillot E, Pétéra M, Jacquemin J, Centeno D, Lyan B, Montoliu I, Madej D, Pietruszka B, Fabbri C, Santoro A, Brzozowska A, Franceschi C, Comte B. Frontiers in Physiology 9.1903 (2019). [Research article]

Systems Metabolomics for Prediction of Metabolic Syndrome. Pujos-Guillot E, Brandolini-Bunlon M, Pétéra M, Grissa D, Joly C, Lyan B, Herquelot E, Czernichow S, Zins M, Goldberg M, Comte B. Journal of Proteome Research 16 (6), 2262-2272(2017). [Research article]

Other links

• https://www.researchgate.net/profile/Estelle-Pujos-Guillot?ev=hdr_xprf
• https://scholar.google.com/citations?user=mXk7f0wAAAAJ&hl=en
• https://orcid.org/0000-0002-4693-5712
• https://www.linkedin.com/in/estelle-pujos-guillot-84449b312/
• PFEM