Research activity

Solving problems related to aging remains an important challenge in human nutrition research. In addition to the pathologies characteristic of old age, aging is associated with a decline in the body's adaptive capacity. One factor explaining this phenomenon is the reduction in muscle protein mass that occurs starting in the third decade of life in humans. Muscle, crucial for locomotion, is also a major site for the oxidation of fatty acids and glucose, and it also constitutes an emergency reserve of amino acids for the body. In cases of stress, the body will draw on muscle for the amino acids it lacks. Overall, a loss of muscle mass will reduce the body's ability to restore a state of good health and risks increasing morbidity and mortality in cases of serious illness. It is therefore important to maintain muscle mass.
With this objective in mind, I am working to better understand nutritional needs, particularly protein needs, in various physiological situations. I am currently working on research aimed at better understanding individual variability in the response of protein metabolism to protein intake. I have shown that the response of muscle protein synthesis to meals decreases with age. What is the individual variability in this phenomenon ?

Most notable publications

• Laurianne Dimina, Justine Landais, Véronique Mathe, Marianne Jarzaguet, Cindy Le Bourgot, Dominique Hermier, François Mariotti, Didier Rémond, Laurent Mosoni. (2023). Plant protein can be as efficient as milk protein to maintain fat free mass in old rats, even when fat and sugar intakes are high. Blended plant protein adequately replaces milk proteins. J Nutr, 153 (9), 2631-2641, https://dx.doi.org/10.1016/j.tjnut.2023.01.025, https://hal.inrae.fr/hal-04197061
• Laurent Mosoni., Marianne Jarzaguet., Jérémie David., Sergio Polakof., Isabelle Savary-Auzeloux, Didier Remond, Dominique Dardevet. (2019). Post meal energy boluses do not increase the duration of muscle protein synthesis stimulation in two anabolic resistant situations. Nutrients, 11 (4), np, https://dx.doi.org/10.3390/nu11040727, https://hal.inrae.fr/hal-02102974.
• Eva Gatineau, Sergio Polakof Requejo, Dominique Dardevet, Laurent Mosoni (2017). Similarities and interactions between the ageing process and high chronic intake of added sugars. Nutrition Research Reviews, Epub ahead of print (2), 1-17, https://dx.doi.org/10.1017/S0954422417000051, https://hal.inrae.fr/hal-01528848
• Eva Gatineau, Frédéric Capel, Dominique Dardevet, Jérémie David, Corinne Pouyet, Sergio Polakof, Laurent Mosoni (2018). Effect of high chronic intake of sucrose on liver metabolism in aging rats. Modulation by rutin and micronutrients. Journal of Physiology and Biochemistry, 74 (4), 9 p., https://dx.doi.org/10.1007/s13105-018-0628-y, https://hal.inrae.fr/hal-01769296
• Eva Gatineau, Isabelle Savary-Auzeloux, Carole Migne, Sergio Polakof, Dominique Dardevet, Laurent Mosoni (2015). Chronic Intake of Sucrose Accelerates Sarcopenia in Older Male Rats through Alterations in Insulin Sensitivity and Muscle Protein Synthesis. Journal of Nutrition, 145 (5), 923-930, https://dx.doi.org/10.3945/jn.114.205583, https://hal.inrae.fr/hal-02630933

Other links

• https://www.linkedin.com/in/laurent-mosoni-a57834236/
• IMPROVING / VaRIAe