Mosoni Laurent
VaRIAe
Researcher

Research activity

Addressing issues related to aging remains a key challenge in human nutrition research. Beyond the pathologies characteristic of advanced age, the aging process is marked by a decline in the body's adaptive capacity. One factor contributing to this phenomenon is the reduction in muscle protein mass, which begins in the third decade of life in humans. Muscle tissue is crucial for locomotion and serves as a major site for fatty acid and glucose oxidation, as well as an emergency reserve of amino acids for the body. Under stress, the body draws upon muscle tissue to obtain the amino acids it lacks. Ultimately, a loss of muscle mass diminishes the body's ability to restore good health and increases the risk of morbidity and mortality in the event of serious illness. Maintaining muscle mass is therefore essential.
With this goal in mind, I am working to better understand nutritional requirements—specifically regarding protein—across various physiological states. My current research focuses on understanding individual variability in how protein metabolism responds to protein intake. I have previously demonstrated that the muscle protein synthesis response to a meal diminishes with age; I am now investigating the extent of individual variability in this phenomenon.

Most notable publications

  • Laurianne Dimina, Justine Landais, Véronique Mathe, Marianne Jarzaguet, Cindy Le Bourgot, Dominique Hermier, François Mariotti, Didier Rémond, Laurent Mosoni. (2023). Plant protein can be as efficient as milk protein to maintain fat free mass in old rats, even when fat and sugar intakes are high. Blended plant protein adequately replaces milk proteins. J Nutr, 153 (9), 2631-2641, https://dx.doi.org/10.1016/j.tjnut.2023.01.025, https://hal.inrae.fr/hal-04197061
     
  • Laurent Mosoni., Marianne Jarzaguet., Jérémie David., Sergio Polakof., Isabelle Savary-Auzeloux, Didier Remond, Dominique Dardevet. (2019). Post meal energy boluses do not increase the duration of muscle protein synthesis stimulation in two anabolic resistant situations. Nutrients, 11 (4), np, https://dx.doi.org/10.3390/nu11040727, https://hal.inrae.fr/hal-02102974.
     
  • Eva Gatineau, Sergio Polakof Requejo, Dominique Dardevet, Laurent Mosoni (2017). Similarities and interactions between the ageing process and high chronic intake of added sugars. Nutrition Research Reviews, Epub ahead of print (2), 1-17, https://dx.doi.org/10.1017/S0954422417000051, https://hal.inrae.fr/hal-01528848
     
  • Eva Gatineau, Frédéric Capel, Dominique Dardevet, Jérémie David, Corinne Pouyet, Sergio Polakof, Laurent Mosoni (2018). Effect of high chronic intake of sucrose on liver metabolism in aging rats. Modulation by rutin and micronutrients. Journal of Physiology and Biochemistry, 74 (4), 9 p., https://dx.doi.org/10.1007/s13105-018-0628-y, https://hal.inrae.fr/hal-01769296
     
  • Eva Gatineau, Isabelle Savary-Auzeloux, Carole Migne, Sergio Polakof, Dominique Dardevet, Laurent Mosoni (2015). Chronic Intake of Sucrose Accelerates Sarcopenia in Older Male Rats through Alterations in Insulin Sensitivity and Muscle Protein Synthesis. Journal of Nutrition, 145 (5), 923-930, https://dx.doi.org/10.3945/jn.114.205583, https://hal.inrae.fr/hal-02630933

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