UNH - Unité de Nutrition Humaine
Our unit
Diary
M
Christophe Montaurier
Image par defaut
Montaurier Christophe
christophe.montaurier@inrae.fr
04 73 17 82 71
INRAE
ASMS
Engineer
Head of the “Indirect Calorimetry” technical platform, and developer of computer applications

Research activity

The Technical Platform is a shared resource that brings together facilities located on two sites:

Two 10 m² Calorimetric Chambers located in Clermont Ferrand at the CRNH d'Auvergne. They enable continuous calculations of human energy expenditure and RQ over long periods, based on measurements of respiratory exchanges (Indirect Calorimetry), in the following areas :

  • Precise calculation of 24-hour energy balance based on monitoring of intake and expenditure
  • Determination of energy expenditure kinetics
  • Assessment of the nutritional needs of a specific population (e.g., athletes)
  • Determination of metabolic disturbances
  • Study of the thermogenic properties of nutrients, medications, and nutritional formulas (diets)
  • Exploration of energy expenditure under normal living conditions

Calorimetric chambers allow for the precise assessment of energy expenditure and the utilization of energy substrates (proteins, lipids, carbohydrates) of an individual living in conditions that allow precise control of their physical activity and diet.

Four calorimetric cages for rats and mice are located in the UNH animal facility at the INRA site in Theix. The principle for measuring the energy expenditure of rats and mice is also based on indirect calorimetry.

Controlling these facilities and analyzing the generated data requires the development of specific programs, particularly in VBA and Matlab.

Most notable publications

  • Le Bacquer O, Combe K, Montaurier C, Salles J, Giraudet C, Patrac V, Domingues-Faria C, Guillet C, Louche K, Boirie Y, Sonenberg N, Moro C, Walrand S. Muscle metabolic alterations induced by genetic ablation of 4E-BP1 and 4E-BP2 in response to diet-induced obesity. Mol Nutr Food Res. 2017 Sep;61(9).
     
  • Chavanelle V, Boisseau N, Otero YF, Combaret L, Dardevet D, Montaurier C, Delcros G, Peltier SL & Sirvent P. Effects of high-intensity interval training and moderate-intensity continuous training on glycaemic control and skeletal muscle mitochondrial function in db/db mice. Sci Rep. 2017 Mar 16;7(1):204. doi: 10.1038/s41598-017-00276-8.
     
  • Pinel A, Pitois E, Rigaudiere JP, Jouve C, De Saint-Vincent S, Laillet B, Montaurier C, Huertas A, Morio B & Capel F. EPA prevents fat mass expansion and metabolic disturbances in mice fed with a Western diet. J Lipid Res. 2016 Jun 15. pii: jlr.M06
     
  • Ennequin G, Boisseau N, Caillaud K, Chavanelle V, Etienne M, Li X, Montaurier C, Sirvent P. Neuregulin 1 affects leptin levels, food intake and weight gain in normal-weight, but not obese, db/db mice. Diabetes Metab. 2015 Jan 5. pii: S1262-3636(14)00197-9. doi: 10.1016/j.diabet.2014.12.002.
     
  • Heng AE, Montaurier C, Cano N, Caillot N, Blot A, Meunier N, Pereira B, Marceau G, Sapin V, Jouve C, Boirie Y, Deteix P, Morio B. Energy expenditure, spontaneous physical activity and with weight gain in kidney transplant recipients. Clin Nutr. 2014 May 15. pii: S0261-5614(14)00134-4. doi: 10.1016/j.clnu.2014.05.003.
     
  • Montaurier C, Morio B, Bannier S, Derost P, Arnaud P, Brandolini-Bunlon M, Giraudet C, Boirie Y, Durif F. Mechanisms of body weight gain in patients with Parkinson's disease after subthalamic stimulation. Brain. 2007 Jul;130(Pt 7):1808-18. Epub 2007 May 29.

Other links