UNH - Unité de Nutrition Humaine
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G
Nicolas Goncalves Mendes
Goncalves Mendes Nicolas
nicolas.goncalves-mendes@uca.fr
04 73 17 80 51
UCA
ECREIN
University Lecturer

Research Activities

Recruited as a University Lecturer since 2005 at the University of Auvergne, I have been a member of the ECREIN research team since its inception. The main focus is the study of immunocompetent cells involved in intercellular dialogue in response to microenvironmental variations and the evaluation of the preventive or therapeutic potential of dietary bioactives.

My research focuses on the immunomodulatory effects of vitamin D. I coordinated a clinical study (DFI, Vitamin D & Immune Functions) in vitamin D-deficient subjects over 65 years of age. The objective was to evaluate the impact of vitamin D supplementation on the functional capacity of immunocompetent cells, before and after activation of the immune system by an influenza vaccine. Since then, my work has focused on the immunomodulatory effects of vitamin D in physiological situations or in the context of mammary carcinogenesis. We have conducted several experimental projects related to nutritional disorders (overweight/obesity), the modulation of immunocompetent cells, and the physical activity component in cancer situations.

I am also interested in the effect of diet and physical activity on metabolic abnormalities and am currently focusing my research on hepatocellular cancer and metabolic-dysfunction-associated fatty liver disease (MAFLD), again using our experimental models. This pathology, partly associated with obesity, is accompanied by numerous metabolic changes. Ultimately, it promotes the development of hepatocellular carcinoma (HCC).

Most notable publications

  • The obese inflammatory microenvironment may promote breast DCIS progression. Habanjar O, Nehme R, Goncalves-Mendes N, Cueff G, Blavignac C, Aoun J, Decombat C, Auxenfans C, Diab-Assaf M, Caldefie-Chézet F, Delort L. Front Immunol. 2024 Jul 12;15:1384354. DOI : 10.3389/fimmu.2024.1384354
  • Volatile Organic Compounds Detected in Amniotic Fluid of Women During Normal Pregnancy. Minet-Quinard R, Goncalves-Mendes N, Gallot D,  Pereira B, Lambert C, Brailova M, Blanchon L,  Bouvier D, Sapin V. Exposure and Health, 2023 Springer. DOI :10.1007/s12403-023-00617-1
  • Impact of Vitamin D Supplementation on Influenza Vaccine Response and Immune Functions in Deficient Elderly Persons: A Randomized Placebo-Controlled Trial. Goncalves-Mendes N, Talvas J, Dualé C, Guttmann A, Corbin V, Marceau G, Sapin V, Brachet P, Evrard B, Laurichesse H, Vasson MP. Front Immunol. 2019 Feb 8;10:65. DOI: 10.3389/fimmu.2019.00065
  • 25-Hydroxyvitamin D potentializes extracellular cathelicidin release from human PBMC stimulated ex vivo with either bacterial (LPS) or viral (P: IC) mimetics. Aldekwer S, Goncalves-Mendes N, Bingula R, Martinroche G, Lanchais K, Rougé S, Farges MC, Rossary A, Diab-Assaf M, Vasson MP, Talvas J. J Physiol Biochem. 2022 Jan 5:1-8.DOI: 10.1007/s13105-021-00868-z
  • Vitamin D supplementation associated with physical exercise promotes a tolerogenic immune environment without effect on mammary tumour growth in C57BL/6 mice. Aldekwer S, Desiderio A, Farges MC, Rougé S, Le Naour A, Le Guennec D, Goncalves-Mendes N, Mille-Hamard L, Momken I, Rossary A, Diab-Assaf M, Vasson MP, Talvas J. Eur J Nutr. 2021 Nov 10.DOI: 10.1007/s00394-020-02420-z  

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