Cécile_Gladine.jpg
Gladine Cécile
VaRIAe
Researcher

Research activities

Dr. Cécile Gladine is a Director of Research at the French National Research Institute for Agriculture, Food and Environment (INRAE). She is a biologist in human nutrition whose research explores the intricate links between diet, lipid mediators, and health. 

Dr. Gladine trained in both France and the United Kingdom. She earned a B.Sc. in Applied Biosciences and Chemistry from Robert Gordon University (Aberdeen, Scotland), followed by a Ph.D. in Nutrition, Biochemistry and Metabolism from the School of Medicine in Clermont-Ferrand, France, in 2006. She joined INRAE as a researcher in 2007 and further expanded her expertise during a postdoctoral fellowship at AgResearch (Palmerston North, New Zealand), within the Food Nutrition Genomics team. There, she investigated the nutrigenomic effects of omega-3 polyunsaturated fatty acids and their protective role in atherosclerosis and inflammation.

For more than 15 years, Dr. Gladine has focused her research on oxylipins, oxygenated metabolites of polyunsaturated fatty acids that play key roles in the regulation of cardiometabolic health and immunity. Oxylipins are particularly important in the control and resolution of inflammation, and a deeper understanding of their metabolism and their interactions with cytokines during inflammatory responses is essential for improving our understanding of inflammation-related diseases. 

By combining clinical research, human nutrition, high-throughput quantitative lipidomics and integrative biostatistical approaches, she investigates how oxylipin metabolism influences cardiometabolic health and inflammation during aging, with a particular interest in the modulation of oxylipin metabolism by diet and its interindividual variability. Ultimately, her research aims to support the development of more precise and personalized strategies for the prevention and management of inflammation-related diseases.

Publications

Karol Parchem, Sophia Letsiou, Toni Petan, Olga Oskolkova, Isabel Medina, Ondrej Kuda, Valerie B O'Donnell, Anna Nicolaou, Maria Fedorova, Valery Bochkov, Cécile Gladine (2024). Oxylipin profiling for clinical research: Current status and future perspectives. Progress in lipid Research, 95, 101276, https://dx.doi.org/10.1016/j.plipres.2024.101276, https://hal.inrae.fr/hal-04604453

Etienne Villain, Aurélie Chanson, Malwina Mainka, Nadja Kampschulte, Pauline Le Faouder, Justine Bertrand-Michel, Marion Brandolini-Bunlon, Bruno Charbit, Munyaradzi Musvosvi, Nicole Bilek ... Cécile Gladine (2023). Integrated analysis of whole blood oxylipin and cytokine responses after bacterial, viral, and T cell stimulation reveals new immune networks. iScience, 26 (8), 107422, https://dx.doi.org/10.1016/j.isci.2023.107422, https://hal.inrae.fr/pasteur-04186166 

Céline Dalle, Jérémy Tournayre, Malwina Mainka, Alicja Basiak-Rasała, Mélanie Pétéra, Sophie Lefèvre-Arbogast, Jessica Dalloux-Chioccioli, Mélanie Deschasaux-Tanguy, Lucie Lécuyer, Emmanuelle Kesse-Guyot ... Cécile Gladine (2022). The Plasma Oxylipin Signature Provides a Deep Phenotyping of Metabolic Syndrome Complementary to the Clinical Criteria. International Journal of Molecular Sciences, 23 (19), 11688, https://dx.doi.org/10.3390/ijms231911688 , https://hal.inrae.fr/hal-03839966

Malwina Mainka, Céline Dalle, Mélanie Pétéra, Jessica Dalloux-Chioccioli, Nadja Kampschulte, Annika Ostermann, Michael Rothe, Justine Bertrand-Michel, John Newman, Cécile Gladine, Nils Helge Schebb. (2020). Harmonized procedures lead to comparable quantification of total oxylipins across laboratories. Journal of Lipid Research, 61 (11), 1424-1436, https://dx.doi.org/10.1194/jlr.RA120000991 , https://hal.inrae.fr/hal-03102029

Rémy Bosviel, Laurie Joumard-Cubizolles, Giulia Chinetti-Gbaguidi, Dominique Bayle, Corinne Copin, Nathalie Hennuyer, Isabelle Duplan, Bart Staels, Giuseppe Zanoni, Alessio Porta, Laurence Balas, Jean-Marie Galano, Camille Oger, André Mazur, Thierry Durand, Cécile Gladine (2017). DHA-derived oxylipins, neuroprostanes and protectins, differentially and dosedependently modulate the inflammatory response in human macrophages: putative mechanisms through PPAR activation. Free Radical Biology and Medicine, 103 146-154, https://dx.doi.org/10.1016/j.freeradbiomed.2016.12.018 , https://hal.inrae.fr/hal-01595235

Projects

  • 2026/2030 PEPR TRANSCEND-ID grant, Acronym : OXYMIC, Coordinator, Research theme: Contribution of oxylipins to the mechanisms of chronic and treatment-refractory inflammation: specificities and convergences across different Chronic Inflammatory Diseases (CIDs), 400 k€ euros, 3 partners (France).
  • 2025/2027 iSITE grant, Acronym : OXYLIPIT, Partner, Research theme : Oxylipins as biomarkers of response to immunotherapy in melanoma, 40 k€, 3 partners (France)
  • 2023/2026 ANR Grant, Acronym : VARIANCE, Coordinator, Research theme: interindividual variability of oxylipin metabolism, 685 k€, 3 partners (France).
  • 2022/2025 iSITE grant, Acronym : OPERA, Coordinator, Research theme: Variability of oxylipin metabolism in rhumatoid arthritis, 120 k€, 3 partners (France/UK).
  • 2017/2021 EU JPI-HDHL Era Net Cofund grant, Acronym : OXYGENATE, Coordinator, Research theme: Oxylipins signature to monitor the cardiometabolic status and its response to dietary intervention, 721 k€, 6 partners (France/Denmark/Germany/Poland/USA).

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