UNH - Unité de Nutrition Humaine
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F
Catherine Felgines
Felgines Catherine
catherine.felgines@uca.fr
04 73 17 80 31
UCA
ECREIN
University Lecturer

Research Activity

Polyphenols are abundant micronutrients in plant-based foods, and their consumption has been linked to a lower risk of chronic diseases. In addition to their antioxidant properties, polyphenols have the ability to regulate the immune response and modulate the inflammatory response.

Research Themes :
-    Study of the bioavailability and metabolism of polyphenols: anthocyanins, flavones, phenylpropane derivatives, etc.
-    Protective effects of polyphenols against colonic inflammation (rat-induced colonic inflammation model)
-    Evaluation of the anti-inflammatory, antioxidant, and antiglycant properties of plants of dietary and medicinal interest
-    Evaluation of the stability of various polyphenolic compounds under digestive conditions using a standardized in vitro digestion protocol

Methodologies used :
- Colonic inflammation model induced in rats by oral administration of dextran sulfate sodium (DSS)
- Standardized in vitro digestion protocol
- Evaluation of antioxidant and antiglycant properties (DPPH, FRAP, ABTS, ORAC tests, inhibition of the formation of advanced glycation end products (AGEs), evaluation of α-glucosidase inhibitory activity, etc.)

Most notable publications

  • Impact of simulated gastrointestinal conditions on antiglycoxidant and a-glucosidase inhibition capacities of cyanidin-3-O-glucoside. Fraisse D., Bred A., Felgines C., Senejoux F. Antioxidants (Basel), 2021, 10, 1670.
  • Stability and antiglycoxidant potential of bilberry anthocyanins in simulated gastrointestinal tract model. Fraisse D., Bred A., Felgines C., Senejoux F. Foods, 2020, 9, 1695.
  • Characterization and quantification of polyphenolic compounds from Adenium obesum leaves. Meda N.R., Fraisse D., Gnoula C., Peyrode C., Texier O., Senejoux F., Felgines C. Chem. Nat. Compd., 2016, 52, 134-135.
  • Polyphenol-rich grape pomace extracts protect against dextran sulfate sodium-induced colitis in rats. Boussenna A., Cholet J., Goncalves-Mendes N., Joubert-Zakeyh J., Fraisse D., Vasson M-P., Texier O., Felgines C. J. Sci. Food Agric., 2016, 96, 1260-1268.
  • Bioavailability of lemon verbena (Aloysia triphylla) polyphenols in rats: impact of colonic inflammation. Felgines C., Fraisse D., Besson C., Vasson M-P., Texier O. Br. J. Nutr., 2014, 110, 1773-1781.

Other links

ECREIN