Research Activities

Physiologist/Nutritionist specializing in muscle wasting and mobility loss in the elderly and in patients. My research project aims to understand, slow, and limit this muscle loss during aging, with the aim of developing nutritional strategies adapted and optimized to the response capacities of seniors, complementing physical activity and medication. The approaches used are integrative, taking into account interactions between other organs involved in muscle homeostasis (liver/muscle interactions, intestines/microbiota/muscle interactions, specific needs of certain organs). We also consider the interactions between different nutrients (proteins/energy substrates/antioxidants) in qualitative and quantitative terms (plant vs. animal proteins, digestion speed, etc.) and the impact of food matrices and their processing on food efficiency in seniors. The senior population is also very heterogeneous in terms of its health status, and we are currently moving towards a more personalized approach to senior nutrition, adapted both in terms of prevention and intervention in the event of a health incident.
Recently involved in several national and international projects :

• JPI MaNuEL 2016-2018 : The Knowledge Hub on Malnutrition in the Elderly
• JPI INTIMIC 2019-2020 : The Knowledge Platform on Microbiota and Health 
• JPI Appetite  2020-2025 : Innovative plAnt Protein fibre and Physical activity solutions to address poor appetite and prevenT undernutrITion in oldEr adults

Most notable publications

• De Marco Castro E, G Valli, C Buffière, C Guillet, B Mullen,  J Pratt, K Horner, S Gola, SB Mittermaier, M Paganini, G De Vito, HM Roche and D Dardevet.  Peripheral Amino Acid Appearance is Lower Following Plant Protein Fibre Products, Compared to Whey Protein and Fibre Ingestion, in Healthy Older Adults Despite Optimised Amino Acid Profile.  Nutrients, 2022 Dec 21;15(1):35. doi: 10.3390/nu15010035. 
• Savary-Auzeloux I, Jarzaguet M, Migne C, Kemeny JL, Novais Gameiro L , Chatel JM, Dardevet D Anti-inflammatory streptococcus Thermophilus CNRZ160 limits sarcopenia induced by low-grade inflammation in older adult rats. Frontiers in Nutrition, 2022 Sep 29;9:986542
• Giron M, Thomas M, Jarzaguet M, Mayeur C, Ferrere G, Noordine ML, Bornes S, Dardevet D, Chassard C and Savary-Auzeloux I. Lacticaseibacillus casei CNCM I-5663 supplementation maintained muscle mass in a model of frail rodents.  Frontiers in Nutrition, Aug 10;9:9287982022  
• Milenkovic D, Capel F, Combaret L ,  Comte B , Dardevet D, Evrard B , Guillet C, Montfoulet LE,  Pinel A ,  Polakof S ,  Pujos-Guillot E ,  Rémond D, Wittrand Y, Savary-Auzeloux I.  Targeting the gut to prevent and counteract metabolic disorders and pathologies during aging. 2022, Critical reviews in Food Science and Nutrition, 2022 Jun 22:1-26.
• Dardevet D, Mosoni L, Savary-Auzeloux I, Peyron MA, Polakof S, Rémond D. Important determinants to take into account to optimize protein nutrition in the elderly: a complex equation but with solutions. Proceedings of the Nutrition Society, 2021

Author of more than 150 international publications : https://www.ncbi.nlm.nih.gov/pubmed/?term=dardevet+d*

IMPROVING Head office