UNH - Unité de Nutrition Humaine
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C
Florence Caldefie-Chezet
Caldefie-Chezet Florence
florence.caldefie-chezet@uca.fr
04 73 17 79 71
UCA
ECREIN
University Professor - Head of the ECREIN team

Areas of expertise

Nutrition, plant bioactives, phytoprobiotics, natural health products, immunocompetent cells, cancer, obesity, inflammation, inflammation-related pathologies, organoids, reconstructed skin, bioprinting. Health innovation.

The main objective of the work carried out is to characterize the response of immunocompetent cells (CICs, i.e. immune cells, adipocytes, endothelial cells, epithelial cells, chondrocytes in particular) to variations in their micro-environment with two major aims :

  • Identify the relationships between immune/inflammatory alterations and metabolic disorders related to nutritional and immune status in physiopathological situations (notably inflammation, obesity, cancer). In this context, our research is more specifically devoted to the study of interactions between mammary epithelial cells (immunocompetent barrier cells) and their microenvironment (adipocytic, immune and inflammatory) in situations of obesity, considered a risk factor for the onset and recurrence of breast cancer in postmenopausal women.
  • Maintain/optimize the response capacities of immunocompetent cells through targeted nutritional interventions in a preventive and/or therapeutic approach. To this end, a strategy for modulating the microenvironment of CICs is developed through the use of known or innovative immunomodulatory food bioactives, in order to prevent the risk of chronic pathology associated with an inflammatory state (obesity, osteoarthritis, etc.).
LABCOM PHYTOPROB 'INOV

Holder of the LABCOM PHYTOPROB’INOV (ANR 2020) with the company GREENTECH (Saint-Beauzire): Development of innovative plants and phytoprobiotics targeting obesity and associated chronic inflammation https://phytoprob.uca.fr/

 

Chaire ProNatS

Since July 2023, Holder of the PRONATS Chair (Natural Health Products), hosted by the UCA Foundation and in collaboration with the SIGMA-Clermont engineering school (P Chalard), aiming to set up efficient and innovative biological screening models (tripartite culture, organoid models, reconstructed skin, bio-printing) and chemical screening for the faster determination of the efficacy and activity of natural health products https://www.uca-fondation.fr/chaires/les-produits-naturels-de-sante/

Web of Science Researcher ID : Référence : U-3378-2018.

Most notable publications

  • Habanjar O, Diab-Assaf M, Caldefie-Chezet F, Delort L. 3D Cell Culture Systems: Tumor Application, Advantages, and Disadvantages. Int. J. Mol. Sci. 2021, 22, 12200.
  • Cholet J, Decombat C, Delort L, Gainche M, Berry A, Ogeron C, Ripoche I, Vareille-Delarbre M, Vermerie M, Fraisse D, Felgines C, Rossary A, Ranouille E, Berthon JY, Tourrette A, Priam J, Saunier E, Troin Y, Senejoux F, Chalard P, Caldefie-Chézet F. Potential Anti-Inflammatory and Chondroprotective Effect of Luzula sylvatica. Int J Mol Sci. 2022 Dec 21;24(1):127. 
  • Nehme R, Diab-Assaf M, Decombat C, Delort L, Caldefie-Chezet F. Targeting Adiponectin in Breast Cancer. Biomedicines. 2022 Nov 17;10(11):2958. 
  • Delort L, Cholet J, Decombat C, Vermerie M, Dumontet C, Castelli F, Fenaille F, Auxenfans C, Rossary A, Caldefie-Chézet F. The adipose microenvironment dysregulates the mammary myoepithelial cells and could participate to the progression of breast cancer. Front. Cell Dev. Biol., 11 January 2021 | 
  • Habanjar O, Maurin AC, Vituret C, Vachias C, Longechamp L, Garnier C, Decombat C, Bourgne C, Diab-Assaf M, Caldefie-Chezet F, Delort L. A bicellular fluorescent ductal carcinoma in situ (DCIS)-like tumoroid to study the progression of carcinoma: practical approaches and optimization. Biomaterials Science, 2023.

Other links

ECREIN

https://www.linkedin.com/in/florence-caldefie-ch%C3%A9zet-50315530/?originalSubdomain=fr