Plantinauv

Contact : F. Caldefie-Chezet (ECREIN)

CONTEXT

The potential for innovation related to the biological activities of plant secondary metabolites is relatively underexploited, yet considerable. The plant kingdom remains a major source of bioactive metabolites and is responsible for more than 50% of the drugs granted marketing authorization between 1980 and 2010. Therefore, teams from Sigma-Clermont (Professor Pierre Chalard, CESMA) and UNH UMR 1019 INRA-UCA (Professor Florence Caldefie-Chézet, ECREIN team) have been pooling their efforts for over 10 years to explore the biological activities (particularly antitumor, analgesic, and anti-inflammatory) of medicinal plants of various origins. Thanks to the complementarities of regional academic skills in this field of activity but also industrial skills (Dômes Pharma, Greentech and Alto Phyto, Nutravita Cluster), we have thus developed a collaborative project aimed at the study and promotion of Auvergne plants with anti-inflammatory activity. The PLANTINAUV project aims to enable the industrial development of innovative nutraceutical, cosmetic and veterinary products from local sourcing and production.

OBJECTIVES

The PLANTINAUV project aims to study medicinal plants from the flora of Auvergne, known for its richness and diversity, which, to date, have been the subject of very little scientific investigation.

The goals of this project are to :

• Identify new plants of nutritional and medicinal interest with anti-inflammatory properties and determine their active ingredients and mechanisms of action.
• Make the characterized bioactives available to industrial partners in order to initiate a quality and standardization process essential for the commercialization of plant-based products. Ultimately, this project will enable the industrial development of innovative cosmetic, nutraceutical, and/or veterinary products from local production, guaranteeing controlled quality and appropriate volume through the establishment of a new regional cultivation and supply chain.

IMPACT

The PLANTINAUV project has identified four plant species that can be used industrially. These different plants are currently undergoing experimental cultivation, which will ultimately enable a regular local supply of plant-based raw materials.

Publications

Cholet, J., Decombat, C., Vareille-Delarbre, M., Gainche, M., Berry, A., Senejoux, F., Ripoche, I., Delort, L., Vermerie, M., Fraisse, D., Felgines, C., Ranouille, E., Berthon, J.-Y., Priam, J., Saunier, E., Tourrette, A., Troin, Y., Thebaud, G., Chalard, P., Caldefie-Chezet, F., 2019. In Vitro Anti-Inflammatory and Immunomodulatory Activities of an Extract from the Roots of Bupleurum rotundifolium. Medicines (Basel) 6.

Cholet, J., Decombat, C., Vareille-Delarbre, M., Gainche, M., Berry, A., Ogéron, C., Ripoche, I., Delort, L., Vermerie, M., Fraisse, D., Felgines, C., Ranouille, E., Berthon, J.-Y., Tourette, A., Troin, Y., Senejoux, F., Chalard, P., Caldefie-Chezet, F., 2019. Comparison of The Anti-Inflammatory and Immunomodulatory Mechanisms of Two Medicinal Herbs: Meadowsweet (Filipendula ulmaria) and Harpagophytum (Harpagophytum procumbens). International Journal of Plant, Animal and Environmental Sciences 9.